In 2025, a Channel 4 documentary revealed results from analysis of Hitler's DNA obtained from bloodstained fabric from his Berlin bunker sofa. The blood sample was authenticated by matching it with DNA from a confirmed male-line relative. The genetic analysis was conducted by Professor Turi King, a geneticist known for identifying the remains of King Richard III, along with Professor Ditte Demontis from Aarhus University and historian Alex Kay from the University of Potsdam.

The DNA analysis revealed that Hitler had genetic markers consistent with Kallmann syndrome, a rare hormonal disorder caused by genetic mutations affecting nerve cells responsible for hormone and smell function. The condition is characterized by delayed or absent puberty, underdeveloped genitalia, fertility problems, and reduced or absent sense of smell. The syndrome affects the PROK2 gene and can result in low testosterone, undescended testicles, and in approximately five percent of cases, micropenis.

A 1923 medical report from Hitler's time in Landsberg Prison documented right-sided cryptorchidism (one undescended testicle), which corroborates the genetic findings. This medical record provides independent confirmation predating the DNA analysis by over a century.

The polygenic risk score analysis conducted by Professor Demontis revealed that Hitler ranked in the top one percent for genetic predisposition to autism spectrum disorder, schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder. This analysis compares common genetic variants in Hitler's genome against population baselines to determine relative risk for developing these conditions.

Hitler developed idiopathic Parkinson's disease, confirmed through extensive documentation by reliable observers, historians, and Dr. Theodor Morell's medical diaries. Symptoms included pronounced tremor of his left hand and arm, shuffling gait, stooped posture, and progressive motor deterioration. These symptoms were visible in newsreels and filmed appearances, particularly from 1942 onward.

Professor Max de Crinis established a formal diagnosis of Parkinson's disease in Hitler in early 1945 and informed SS leadership. The SS decided to initiate treatment with a specially prepared antiparkinsonian mixture, but Hitler never received this medication, leading to speculation that the SS intended to remove the severely diseased Führer from power.

By March 1945, Hitler's last public appearance showed a dramatically aged and trembling figure. Witnesses described him as appearing far older than his fifty-six years, with uncontrollable hand tremors, difficulty walking, and overall physical deterioration. General Nikolaus von Vormann, who met Hitler in September 1944, noted that Hitler spoke so softly and hesitantly it was difficult to understand him, and his hands trembled so severely he had to grip them between his knees.

From the 1930s onward, Hitler suffered from persistent stomach pains, recurring abdominal pain, chronic flatulence, and other digestive ailments. These conditions were well-documented by his personal physician and multiple observers in his inner circle. Hitler adopted an increasingly restrictive diet, eventually becoming largely vegetarian, though he maintained a strong preference for sweets and would often consume multiple cream cakes at one sitting.

Hitler developed eczema on his legs and had a non-cancerous polyp removed from his throat in 1936. He suffered from chronic flatulence so severe that it became legendary among his staff, with some of his doctors euphemistically calling it "meteorism" due to its violence and frequency.

Hitler was taking Dr. Koester's Anti-Gas Pills multiple times daily by 1944. When ear, nose, and throat specialist Dr. Giesing examined Hitler after he developed jaundice following an assassination attempt, he discovered these pills contained strychnine and belladonna. Giesing tested the pills on himself and found their harmful effects, determining that the strychnine was causing Hitler's jaundice.

For the last nine years of Hitler's life, Dr. Theodor Morell served as his personal physician after being recommended by Hitler's photographer Heinrich Hoffmann in 1936. Morell prescribed Hitler an extensive and bizarre array of medications, often for undisclosed reasons. By the war years, Hitler was prescribed ninety different medications and took many pills each day for chronic conditions.

Morell's unconventional treatments included topical cocaine (likely as eye drops), injected amphetamines (particularly Pervitin/methamphetamine before speeches and when Hitler needed a boost), intravenous glucose, testosterone, estradiol, corticosteroids, morphine-based painkillers, barbiturates for sleep, and low-dose strychnine to ease flatulence. He also administered preparations made from gun cleaner, compounds of strychnine and atropine, extract of seminal vesicles, and numerous vitamins and tonics.

By autumn 1944, Hitler was taking sixty pills daily, ranging from stimulants to poisons. He took pills to wake up and pills to sleep. His secretaries noticed continuous knee shaking and trembling even when seated. Hitler's entourage viewed Morell negatively, complaining about his crude table manners and poor hygiene. Morell was morbidly obese and in extremely poor health himself, dying in 1948 at age sixty-one.

Hitler had a severe dental phobia documented by his personal dentist, Johannes Blaschke. Due to this phobia, Hitler suffered from multiple tooth abscesses, gum infections, and had predominantly false teeth by his later years. His breath was notoriously bad according to contemporaries. These dental details were later published in a biography of Blaschke titled "Dentist of the Devil."

Hitler had an obsessive horror of venereal diseases, devoting extensive passages in Mein Kampf to syphilis, which he called a "Jewish disease." He considered venereal disease one consequence of failure to maintain racial purity of Aryans. Despite this obsession, Dr. Morell did treat Hitler with medications commonly used for syphilis at the time, including Arsenobenzol, Salvarsan, Neosalvarsan with bismuth, and iodine salts, though Morell's specialty was obstetrics and gynecology rather than venereology.

The preponderance of evidence suggests Hitler did not have incapacitating syphilis. Medical historians note that Hitler was sexually inactive throughout much of his life, making infection less likely. While Hitler's progressive mental and physical deterioration after 1942, including paranoia, rage, grandiosity, and possible dementia symptoms, could fit neurosyphilis, repeated clinical examinations failed to show characteristic signs of dementia paralytica or tabes dorsalis. Alternative explanations for his terminal syndrome, including Parkinson's disease and drug effects, are considered more probable.

Adolf Hitler was a lifelong hypochondriac who maintained obsessive health habits. He neither smoked nor drank alcohol, and forbade anyone from doing so in his presence. He was terrified of cancer, which had killed his mother Klara at age forty-seven, and developed premonitions of an early death that haunted him throughout his adult life.

Hitler was described as frail and sickly during childhood. As an adult, despite generally good health in his younger years, he became increasingly preoccupied with illness. He studied medical textbooks, examined instruments left by his doctors, and spent hours obsessing over his symptoms. In September 1944, he took to his bed and spent days staring at the ceiling of his bunker bedroom as if he had forgotten about the war.

By late 1944, Hitler had become what observers described as "a nervous hypochondriac under the spell of several dubious medical consultants who had wormed their way into the bizarre world of Hitler's court, creating a culture of dependency." A panzer general visiting on September 26, 1944, remembered encountering "a tired, broken man who greeted me, then shuffled over to a chair."

Prominent historians including William Carr, Gerhard Weinberg, and Ian Kershaw have documented that Hitler repeatedly claimed he must lead Germany into war before he became too old, as his successors might lack his strength of will. Hitler explicitly stated his fear that he did not have much time left to accomplish his goals.

Hitler's health declined precipitously from 1942 through his suicide in 1945. The once sociable Führer became an isolated hermit living primarily in underground headquarters, convinced that only he could lead Germany to victory but also convinced that assassination awaited around every corner. He rarely left the protection of his bunker, surrounding himself only with his doctor, secretaries, and compliant generals.

Witnesses documented Hitler's deteriorating condition during this period: severe sleep deprivation, exhaustion from drug combinations, stomach cramps that plagued him even in bed, uncontrollable trembling in his left limbs even while lying down, increasingly violent breaking of wind, mood swings ranging from rage to despair, and progressive cognitive decline. Ernst-Günther Schenck, who worked at the Reich Chancellery casualty station in April 1945, witnessed Hitler's final condition but admitted he was himself extremely exhausted and dazed during these encounters.

Hitler celebrated his fifty-sixth birthday in the bunker eight days before his suicide on April 30, 1945. Film footage from his last public appearance on March 20, 1945, shows a stooped, trembling figure reviewing teenage Volkssturm defenders in the Reich Chancellery garden. His hand flapped uncontrollably behind his back, and he appeared decades older than his actual age.

Hitler committed suicide on April 30, 1945, around 3:30 PM after selecting Admiral Karl Dönitz as his successor. According to bunker personnel including Baur, Linge, and Kempka, Hitler shot himself through the mouth while simultaneously taking cyanide. Eva Braun, whom he had married approximately forty hours earlier, died from cyanide poisoning.

In 1968, Soviet archives provided autopsy details of two partially burned bodies found beneath the Reich Chancellery ruins on May 5, 1945, presumptively identified as Hitler and Eva Braun. However, a 2009 History Channel documentary involving University of Connecticut forensic experts examined skull fragments the Soviets claimed belonged to Hitler. DNA testing of these fragments definitively proved they did not belong to Hitler, throwing previous Soviet claims into question.