Tularemia: Biomedical Mechanics
Francisella tularensis is the bacterial agent that causes the disease tularemia or rabbit fever. The bacterium is a intracellular parasite that proliferates inside cells. The bacterium infects mostly mononuclear phagocytes, but can invade other cells as well. Inside the macrophage cell, the bacterium grows until the cell is compromised. In mice, the macrophages die of cytopathogenicity and apoptosis within 24-48 hours.
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